"Today, the hegemonic system should account for its crimes before the world public opinion," Rayeesi said on Tuesday.
He expressed confidence that innocent people's blood shed by the American regime in and outside the United States "certainly sparks (unrests) and will entangle the US and the hegemonic system in fire, and their fate will be condemnation and annihilation".
Rayeesi called on the world human rights and legal bodies to show reaction to the US crimes against its people and the world nations, stressing the need for putting the American statesmen on trial.
In relevant remarks on Monday, Iranian Foreign Ministry Spokesman Seyed Abbas Mousavi in a message to the US officials and police asked for end of state violence against the American people by the Washington regime, cautioning the White House rulers that the world is watching their brutal behavior.
Mousavi made the remarks in a press conference in Tehran in reaction to the recent incidents and daylight violence against the US protestors after the death of a black man by the police.
He first addressed the American people, saying, "The world has heard your outcry over the state oppression. The world is standing with you. The American regime is pursuing violence and bullying at home and abroad."
"We are greatly regretful to see along the people across the world the violent scenes that the US police have recently unfolded. We deeply regret to see the American people who peacefully seek respect and no more violence are suppressed indiscriminately and met with utmost violence."
Mousavi then addressed the American officials and police, saying, "Stop violence against your people and let them breathe."
The Iranian foreign ministry had also on Sunday called on the White House to stop intimidation of protestors and listen to the American people's voice.
"Failed to keep its promise of stopping wasting money on foreign adventurism and embattled in a Covid-19 crisis of its own making, US regime now employs army, vicious dogs and ominous weapons to intimidate protesters," the Iranian foreign ministry wrote on its official twitter page.
It underlined the need for the US to "listen to its people and change its bankrupt policies".
Protests erupt for a 7th day across the US over the death of George Floyd, an unarmed black man, at the hands of a police officer in Minneapolis, Minnesota.
At least 40 cities have imposed curfews and National Guard members have been activated in 15 states and Washington, DC.
One former officer, who was seen with his knee on Floyd's neck, was charged with third-degree murder and manslaughter but protesters say the charge isn't harsh enough, and are demanding charges for the other officers involved.